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Intravascular hemolysis

MedGen UID:
536415
•Concept ID:
C0235574
•
Finding
Synonyms: Hemolyses, Intravascular; Hemolysis, Intravascular; Intravascular Hemolyses; Intravascular Hemolysis
SNOMED CT: Intravascular hemolysis (15601008)

Professional guidelines

PubMed

Paroxysmal Nocturnal Hemoglobinuria: Biology and Treatment.
Bravo-Perez C, Guarnera L, Williams ND, Visconte V
Medicina (Kaunas) 2023 Sep 6;59(9) doi: 10.3390/medicina59091612. PMID: 37763731Free PMC Article
Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.
Barcellini W, Fattizzo B
Dis Markers 2015;2015:635670. Epub 2015 Dec 27 doi: 10.1155/2015/635670. PMID: 26819490Free PMC Article
Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review.
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C
Eur J Haematol 2015 Sep;95(3):190-8. Epub 2015 Mar 26 doi: 10.1111/ejh.12543. PMID: 25753400

Recent clinical studies

Etiology

Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria.
Hillmen P, Szer J, Weitz I, Röth A, Höchsmann B, Panse J, Usuki K, Griffin M, Kiladjian JJ, de Castro C, Nishimori H, Tan L, Hamdani M, Deschatelets P, Francois C, Grossi F, Ajayi T, Risitano A, Peffault de Latour R
N Engl J Med 2021 Mar 18;384(11):1028-1037. doi: 10.1056/NEJMoa2029073. PMID: 33730455
How I treat paroxysmal nocturnal hemoglobinuria.
Brodsky RA
Blood 2021 Mar 11;137(10):1304-1309. doi: 10.1182/blood.2019003812. PMID: 33512400Free PMC Article
Managing hemolyzed samples in clinical laboratories.
Simundic AM, Baird G, Cadamuro J, Costelloe SJ, Lippi G
Crit Rev Clin Lab Sci 2020 Jan;57(1):1-21. Epub 2019 Oct 11 doi: 10.1080/10408363.2019.1664391. PMID: 31603708
Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? A Position Paper From the SAAWP of the EBMT.
Risitano AM, Marotta S, Ricci P, Marano L, Frieri C, Cacace F, Sica M, Kulasekararaj A, Calado RT, Scheinberg P, Notaro R, Peffault de Latour R
Front Immunol 2019;10:1157. Epub 2019 Jun 14 doi: 10.3389/fimmu.2019.01157. PMID: 31258525Free PMC Article
Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review.
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C
Eur J Haematol 2015 Sep;95(3):190-8. Epub 2015 Mar 26 doi: 10.1111/ejh.12543. PMID: 25753400

Diagnosis

Paroxysmal nocturnal hemoglobinuria: Review of the patient experience and treatment landscape.
Waheed A, Shammo J, Dingli D
Blood Rev 2024 Mar;64:101158. Epub 2023 Nov 29 doi: 10.1016/j.blre.2023.101158. PMID: 38071133
How I treat paroxysmal nocturnal hemoglobinuria.
Brodsky RA
Blood 2021 Mar 11;137(10):1304-1309. doi: 10.1182/blood.2019003812. PMID: 33512400Free PMC Article
Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.
Barcellini W, Fattizzo B
Dis Markers 2015;2015:635670. Epub 2015 Dec 27 doi: 10.1155/2015/635670. PMID: 26819490Free PMC Article
Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review.
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C
Eur J Haematol 2015 Sep;95(3):190-8. Epub 2015 Mar 26 doi: 10.1111/ejh.12543. PMID: 25753400
Hemolytic anemia.
Dhaliwal G, Cornett PA, Tierney LM Jr
Am Fam Physician 2004 Jun 1;69(11):2599-606. PMID: 15202694

Therapy

Paroxysmal nocturnal hemoglobinuria: Where are we going.
Kulasekararaj AG, Lazana I
Am J Hematol 2023 May;98 Suppl 4:S33-S43. doi: 10.1002/ajh.26882. PMID: 36794458
Paroxysmal nocturnal hemoglobinuria: Where we stand.
Panse J
Am J Hematol 2023 May;98 Suppl 4:S20-S32. Epub 2023 Jan 16 doi: 10.1002/ajh.26832. PMID: 36594182
Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria.
Hillmen P, Szer J, Weitz I, Röth A, Höchsmann B, Panse J, Usuki K, Griffin M, Kiladjian JJ, de Castro C, Nishimori H, Tan L, Hamdani M, Deschatelets P, Francois C, Grossi F, Ajayi T, Risitano A, Peffault de Latour R
N Engl J Med 2021 Mar 18;384(11):1028-1037. doi: 10.1056/NEJMoa2029073. PMID: 33730455
How I treat paroxysmal nocturnal hemoglobinuria.
Brodsky RA
Blood 2021 Mar 11;137(10):1304-1309. doi: 10.1182/blood.2019003812. PMID: 33512400Free PMC Article
Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? A Position Paper From the SAAWP of the EBMT.
Risitano AM, Marotta S, Ricci P, Marano L, Frieri C, Cacace F, Sica M, Kulasekararaj A, Calado RT, Scheinberg P, Notaro R, Peffault de Latour R
Front Immunol 2019;10:1157. Epub 2019 Jun 14 doi: 10.3389/fimmu.2019.01157. PMID: 31258525Free PMC Article

Prognosis

Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.
Barcellini W, Fattizzo B
Dis Markers 2015;2015:635670. Epub 2015 Dec 27 doi: 10.1155/2015/635670. PMID: 26819490Free PMC Article
Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients.
Barcellini W, Fattizzo B, Zaninoni A, Radice T, Nichele I, Di Bona E, Lunghi M, Tassinari C, Alfinito F, Ferrari A, Leporace AP, Niscola P, Carpenedo M, Boschetti C, Revelli N, Villa MA, Consonni D, Scaramucci L, De Fabritiis P, Tagariello G, Gaidano G, Rodeghiero F, Cortelezzi A, Zanella A
Blood 2014 Nov 6;124(19):2930-6. Epub 2014 Sep 16 doi: 10.1182/blood-2014-06-583021. PMID: 25232059
Paroxysmal nocturnal hemoglobinuria.
Parker CJ
Curr Opin Hematol 2012 May;19(3):141-8. doi: 10.1097/MOH.0b013e328351c348. PMID: 22395662
Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival.
Kelly RJ, Hill A, Arnold LM, Brooksbank GL, Richards SJ, Cullen M, Mitchell LD, Cohen DR, Gregory WM, Hillmen P
Blood 2011 Jun 23;117(25):6786-92. Epub 2011 Apr 1 doi: 10.1182/blood-2011-02-333997. PMID: 21460245
Quinine toxicity.
Bateman DN, Dyson EH
Adverse Drug React Acute Poisoning Rev 1986 Winter;5(4):215-33. PMID: 3548270

Clinical prediction guides

The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target.
Risitano AM, Frieri C, Urciuoli E, Marano L
Immunol Rev 2023 Jan;313(1):262-278. Epub 2022 Sep 15 doi: 10.1111/imr.13137. PMID: 36110036Free PMC Article
Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria.
Hillmen P, Szer J, Weitz I, Röth A, Höchsmann B, Panse J, Usuki K, Griffin M, Kiladjian JJ, de Castro C, Nishimori H, Tan L, Hamdani M, Deschatelets P, Francois C, Grossi F, Ajayi T, Risitano A, Peffault de Latour R
N Engl J Med 2021 Mar 18;384(11):1028-1037. doi: 10.1056/NEJMoa2029073. PMID: 33730455
Managing hemolyzed samples in clinical laboratories.
Simundic AM, Baird G, Cadamuro J, Costelloe SJ, Lippi G
Crit Rev Clin Lab Sci 2020 Jan;57(1):1-21. Epub 2019 Oct 11 doi: 10.1080/10408363.2019.1664391. PMID: 31603708
Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.
Barcellini W, Fattizzo B
Dis Markers 2015;2015:635670. Epub 2015 Dec 27 doi: 10.1155/2015/635670. PMID: 26819490Free PMC Article
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.
Hillmen P, Young NS, Schubert J, Brodsky RA, Socié G, Muus P, Röth A, Szer J, Elebute MO, Nakamura R, Browne P, Risitano AM, Hill A, Schrezenmeier H, Fu CL, Maciejewski J, Rollins SA, Mojcik CF, Rother RP, Luzzatto L
N Engl J Med 2006 Sep 21;355(12):1233-43. doi: 10.1056/NEJMoa061648. PMID: 16990386

Recent systematic reviews

Outcomes of percutaneous temporary biventricular mechanical support: a systematic review.
Weber MP, O'Malley TJ, Choi JH, Maynes EJ, Prochno KW, Austin MA, Wood CT, Patel S, Morris RJ, Massey HT, Tchantchaleishvili V
Heart Fail Rev 2022 May;27(3):879-890. doi: 10.1007/s10741-020-09971-7. PMID: 32458216
Hemolysis in patients with Extracorporeal Membrane Oxygenation therapy for severe Acute Respiratory Distress Syndrome - a systematic review of the literature.
Materne LA, Hunsicker O, Menk M, Graw JA
Int J Med Sci 2021;18(8):1730-1738. Epub 2021 Feb 18 doi: 10.7150/ijms.50217. PMID: 33746589Free PMC Article

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